距離東京奧運(yùn)會(huì)還有不到90天,。
原定于去年夏天舉辦的2020年奧運(yùn)會(huì)被推遲之后,,又經(jīng)過了接近一年的準(zhǔn)備,然而日本疫苗接種工作毫無起色,,導(dǎo)致絕大多數(shù)國(guó)民面對(duì)再次大幅增加的新冠肺炎感染病例,,得不到充分保護(hù)。
4月23日,,日本經(jīng)濟(jì)大臣西村康稔宣布,,東京和大阪以及另外兩個(gè)縣從4月25日開始進(jìn)入緊急狀態(tài)。日本每日新增病例突破5,000例,,僅次于今年1月的首輪疫情高峰,。
西村康稔于4月23日宣布的措施是日本自疫情爆發(fā)以來執(zhí)行的最嚴(yán)格的防疫措施。防疫措施要求大型酒吧和餐廳停業(yè),,并且在5月11日之前禁止觀眾現(xiàn)場(chǎng)觀看體育比賽,。
面對(duì)確診病例激增,日本首相菅義偉所在的自民黨干事長(zhǎng)二階俊博上周對(duì)東京能否舉辦奧運(yùn)會(huì)提出了質(zhì)疑,。
但在宣布最新緊急措施之前,菅義偉還曾經(jīng)在4月20日強(qiáng)調(diào),,防疫政策不會(huì)影響夏季奧運(yùn)會(huì),。
他在4月20日對(duì)記者表示:“奧運(yùn)會(huì)不會(huì)受到影響,。政府將繼續(xù)全力以赴安全成功地舉辦奧運(yùn)會(huì),?!?/p>
日本已經(jīng)禁止外國(guó)觀眾參加奧運(yùn)會(huì),并且發(fā)布了一系列規(guī)定,,以避免運(yùn)動(dòng)員、官員和媒體工作人員在東京期間感染和傳播新冠病毒,。
這屆奧運(yùn)會(huì)對(duì)于參與人員沒有接種疫苗的要求,但運(yùn)動(dòng)員在抵達(dá)東京時(shí)需要接受檢測(cè),,并且在東京停留期間還要定期檢測(cè)。運(yùn)動(dòng)員不得聚餐或聚集,,必須避免身體接觸,,例如拍手慶祝和握手等,。
不過依舊有專家擔(dān)心,有來自93個(gè)國(guó)家數(shù)以萬計(jì)的運(yùn)動(dòng)員,、教練員和代表團(tuán)成員計(jì)劃前往東京停留13周,,面對(duì)這種局面,這些措施可能不足以避免發(fā)生超級(jí)傳播者事件的威脅,。
對(duì)于奧運(yùn)會(huì)的各種擔(dān)憂,,以及最近感染人數(shù)的大幅增加,使日本進(jìn)展緩慢的疫苗接種工作備受關(guān)注,。日本大部分國(guó)民沒有接種疫苗,,疫苗接種工作遠(yuǎn)遠(yuǎn)落后于其他主要經(jīng)濟(jì)體。
作為全球第三大經(jīng)濟(jì)體,,日本并不缺乏采購(gòu),、分配甚至生產(chǎn)新冠疫苗的資源或能力。但盡管面臨要在疫情期間舉辦奧運(yùn)會(huì)的額外壓力,,日本依舊選擇了緩慢穩(wěn)定地推進(jìn)疫苗接種,,導(dǎo)致新冠病毒給日本帶來的風(fēng)險(xiǎn)并沒有明顯減少,。
疫苗接種
日本在批準(zhǔn)美國(guó)制藥業(yè)巨頭輝瑞(Pfizer)和德國(guó)疫苗制造商BioNTech開發(fā)的新冠疫苗幾天之后,于2月17日正式啟動(dòng)疫苗接種,。這比美國(guó)等國(guó)家已經(jīng)落后了幾個(gè)月,,但政府官員依舊樂觀地認(rèn)為日本能夠迎頭趕上。
日本最初計(jì)劃在3月為370萬醫(yī)護(hù)人員接種疫苗,,而且菅義偉承諾在今年上半年,,為日本1.26億人口保證足夠的疫苗供應(yīng)。
但截至4月21日,,日本僅施打了200多萬劑疫苗,,相當(dāng)于只有1%的人口接種了疫苗。
相比之下,,中國(guó),、美國(guó)、歐盟,、印度和巴西等其他大型經(jīng)濟(jì)體的疫苗接種工作已經(jīng)遙遙領(lǐng)先于日本,。
日本表示,疫苗供應(yīng)問題延誤了初期的接種工作,,并指責(zé)歐洲的出口限制導(dǎo)致日本無法確定疫苗分配計(jì)劃,。《財(cái)富》雜志曾經(jīng)咨詢?nèi)毡菊侥壳盀橹挂呀?jīng)取得了多少劑疫苗,,但并未得到回應(yīng),。
但有人認(rèn)為日本至少應(yīng)該承擔(dān)一定的責(zé)任。
到目前為止,,日本嚴(yán)格的疫苗監(jiān)管制度僅批準(zhǔn)了輝瑞疫苗,,它們要求疫苗生產(chǎn)商在日本完成安全性試驗(yàn)之后才可以獲得批準(zhǔn)。
日本也從英國(guó)阿斯利康和美國(guó)Moderna采購(gòu)了疫苗,,但衛(wèi)生部門尚未批準(zhǔn)這兩款疫苗,。
仙臺(tái)白百合女子大學(xué)的日本政治專家塞巴斯蒂安·馬斯洛指出,復(fù)雜的政府官僚政治可能讓情況變得更加復(fù)雜,。馬斯洛表示,,今年1月,日本任命行政改革擔(dān)當(dāng)大臣河野太郎主持疫苗分配工作,,這一決定可能使疫苗接種工作出現(xiàn)混亂,。
馬斯洛稱:“特別任命一位內(nèi)閣大臣負(fù)責(zé)協(xié)調(diào)疫苗分配讓情況變得更復(fù)雜”,因?yàn)椤耙呙缃臃N的具體工作”實(shí)際上是由衛(wèi)生部門負(fù)責(zé),。
馬斯洛說:“菅義偉政府的響應(yīng)速度極其緩慢,。”
但疫苗接種進(jìn)展緩慢有一部分原因是有意為之,。
日本當(dāng)局之所以比美國(guó)晚幾個(gè)月批準(zhǔn)輝瑞疫苗,,按照政府的說法是因?yàn)槿毡鞠M谌澜鐚?duì)是否接種疫苗最猶豫不決的時(shí)候,,盡可能讓公眾樹立對(duì)疫苗的信心。
醫(yī)學(xué)期刊《柳葉刀》在2020年9月發(fā)表的一項(xiàng)調(diào)查發(fā)現(xiàn),,認(rèn)為疫苗安全有效的日本受訪者不足30%,,而美國(guó)受訪者的比例超過50%。
最近幾個(gè)月,,公眾似乎認(rèn)可了新冠疫苗,,并開始對(duì)政府的行動(dòng)遲緩日益不滿。
東京大學(xué)在3月調(diào)查發(fā)現(xiàn),,62%的日本受訪者愿意接種新冠疫苗,。4月12日,日本共同社公布了對(duì)1,000名日本民眾的調(diào)查結(jié)果,,其中60%的受訪者表示“不滿意”政府的疫苗接種工作,,表示滿意的只有37%。
日本的疫苗生產(chǎn)
日本對(duì)外國(guó)疫苗的依賴引發(fā)了另外一個(gè)問題:日本作為全球第三大醫(yī)藥市場(chǎng),,有武田制藥,、安斯泰來制藥和第一三共等行業(yè)巨頭,為什么國(guó)內(nèi)沒有開發(fā)出有效的新冠疫苗,?
世界衛(wèi)生組織的報(bào)告稱,,截至4月20日,全世界已經(jīng)有91款新冠疫苗開始進(jìn)行人體試驗(yàn),。其中有四款是日本疫苗,,但日本企業(yè)都沒有完成三期臨床試驗(yàn),而三期臨床試驗(yàn)是獲得監(jiān)管審批之前的最后一步,。
誕生于大阪大學(xué)的初創(chuàng)制藥公司AnGes Inc.在日本新冠疫苗開發(fā)方面進(jìn)展最快。該公司在去年12月啟動(dòng)了基于DNA的候選疫苗的二期和三期臨床試驗(yàn),。
日本藥企第一三共正在開發(fā)一款mRNA疫苗,。該公司表示其疫苗最早要在2022年4月才能夠上市?!度毡緯r(shí)報(bào)報(bào)道稱,,日本制藥行業(yè)業(yè)內(nèi)人士同樣預(yù)計(jì),最早要到明年4月才會(huì)有日本國(guó)產(chǎn)疫苗上市,。
疫苗產(chǎn)能似乎并不是日本疫苗開發(fā)面臨的主要障礙,,因?yàn)槿毡舅幤笈c外國(guó)藥企達(dá)成了大規(guī)模生產(chǎn)疫苗的協(xié)議。
日本藥企第一三共,、KM Biologics和JCR Pharmaceuticals每年將合作生產(chǎn)1.2億劑阿斯利康的疫苗,。武田制藥則與美國(guó)藥企Novavax合作,每年在日本生產(chǎn)2.5億劑新冠疫苗,。
馬斯洛表示,,由于缺乏政府支持,,日本的疫苗開發(fā)系統(tǒng)不能與美國(guó)等國(guó)家的同行一樣幫助推動(dòng)創(chuàng)新。
馬斯洛稱:“多年來,,日本始終沒有為科研和疫苗開發(fā)提供足夠的財(cái)政支持,。”
日本確實(shí)向疫苗生產(chǎn)商撥款近30億美元,,以促進(jìn)新冠疫苗的開發(fā),。但這筆投資顯然遠(yuǎn)遠(yuǎn)低于諸如投入180億的“曲速行動(dòng)”等旨在加快新冠疫苗開發(fā)的項(xiàng)目。
日本政府對(duì)疫苗開發(fā)工作的支持不足,,部分原因可以追溯到幾十年前的疫苗丑聞,。
20世紀(jì)80年代末和90年代初,麻疹,、腮腺炎,、風(fēng)疹三聯(lián)疫苗在日本被曝出可能與類似于流感的少量無菌性腦膜炎病例有關(guān),盡管這種疫苗在全世界已經(jīng)使用了數(shù)十年,,其安全性和療效也得到了證明,。
90年代初,因?yàn)楹⒆咏臃N疫苗后出現(xiàn)嚴(yán)重副作用而提起訴訟的三個(gè)家庭勝訴,,其中有兩名兒童死亡,。法院裁定日本政府因?yàn)橥扑]接種這款疫苗,需要對(duì)此負(fù)責(zé),。
事后,,日本停止接種MMR疫苗,直到今天,,它依舊是少數(shù)不使用這款疫苗的主要經(jīng)濟(jì)體之一,。
威爾遜中心的地理經(jīng)濟(jì)學(xué)副主任藤志保子表示,MMR疫苗以及其他疫苗爭(zhēng)議的影響妨礙了日本疫苗開發(fā)行業(yè)的發(fā)展,,讓政府在選擇支持疫苗制造商時(shí)變得更加謹(jǐn)慎,。
面對(duì)新冠疫情,日本對(duì)待疫苗小心謹(jǐn)慎的態(tài)度導(dǎo)致政府和制藥商將重心放到開發(fā)治療藥物而不是疫苗,,例如富士膠片的流感藥物Avigan,。這款藥物在減少新冠肺炎癥狀方面的結(jié)果好壞參半。
藤志保子稱:“日本的應(yīng)對(duì)方式并不是開發(fā)疫苗,,而是寧可小心謹(jǐn)慎,,也不愿意冒風(fēng)險(xiǎn)?!毕喾?,她表示:“日本政府把所有雞蛋都放到了‘治療藥物’這個(gè)籃子里,但事情的發(fā)展卻并不像他們所想象的那樣,?!?/p>
從根本上來說,,日本應(yīng)對(duì)新冠病毒的表現(xiàn),要好于美國(guó)和歐洲國(guó)家,。但其在研發(fā)和接種疫苗方面進(jìn)展緩慢,,可能成為三個(gè)月后舉辦奧運(yùn)會(huì)面臨的致命弱點(diǎn)。(財(cái)富中文網(wǎng))
翻譯:劉進(jìn)龍
審校:汪皓
距離東京奧運(yùn)會(huì)還有不到90天,。
原定于去年夏天舉辦的2020年奧運(yùn)會(huì)被推遲之后,,又經(jīng)過了接近一年的準(zhǔn)備,然而日本疫苗接種工作毫無起色,,導(dǎo)致絕大多數(shù)國(guó)民面對(duì)再次大幅增加的新冠肺炎感染病例,,得不到充分保護(hù)。
4月23日,,日本經(jīng)濟(jì)大臣西村康稔宣布,,東京和大阪以及另外兩個(gè)縣從4月25日開始進(jìn)入緊急狀態(tài)。日本每日新增病例突破5,000例,,僅次于今年1月的首輪疫情高峰,。
西村康稔于4月23日宣布的措施是日本自疫情爆發(fā)以來執(zhí)行的最嚴(yán)格的防疫措施。防疫措施要求大型酒吧和餐廳停業(yè),,并且在5月11日之前禁止觀眾現(xiàn)場(chǎng)觀看體育比賽,。
面對(duì)確診病例激增,日本首相菅義偉所在的自民黨干事長(zhǎng)二階俊博上周對(duì)東京能否舉辦奧運(yùn)會(huì)提出了質(zhì)疑,。
但在宣布最新緊急措施之前,,菅義偉還曾經(jīng)在4月20日強(qiáng)調(diào),防疫政策不會(huì)影響夏季奧運(yùn)會(huì),。
他在4月20日對(duì)記者表示:“奧運(yùn)會(huì)不會(huì)受到影響,。政府將繼續(xù)全力以赴安全成功地舉辦奧運(yùn)會(huì)?!?/p>
日本已經(jīng)禁止外國(guó)觀眾參加奧運(yùn)會(huì),,并且發(fā)布了一系列規(guī)定,以避免運(yùn)動(dòng)員,、官員和媒體工作人員在東京期間感染和傳播新冠病毒,。
這屆奧運(yùn)會(huì)對(duì)于參與人員沒有接種疫苗的要求,,但運(yùn)動(dòng)員在抵達(dá)東京時(shí)需要接受檢測(cè),,并且在東京停留期間還要定期檢測(cè)。運(yùn)動(dòng)員不得聚餐或聚集,,必須避免身體接觸,,例如拍手慶祝和握手等。
不過依舊有專家擔(dān)心,,有來自93個(gè)國(guó)家數(shù)以萬計(jì)的運(yùn)動(dòng)員,、教練員和代表團(tuán)成員計(jì)劃前往東京停留13周,,面對(duì)這種局面,這些措施可能不足以避免發(fā)生超級(jí)傳播者事件的威脅,。
對(duì)于奧運(yùn)會(huì)的各種擔(dān)憂,,以及最近感染人數(shù)的大幅增加,使日本進(jìn)展緩慢的疫苗接種工作備受關(guān)注,。日本大部分國(guó)民沒有接種疫苗,,疫苗接種工作遠(yuǎn)遠(yuǎn)落后于其他主要經(jīng)濟(jì)體。
作為全球第三大經(jīng)濟(jì)體,,日本并不缺乏采購(gòu),、分配甚至生產(chǎn)新冠疫苗的資源或能力。但盡管面臨要在疫情期間舉辦奧運(yùn)會(huì)的額外壓力,,日本依舊選擇了緩慢穩(wěn)定地推進(jìn)疫苗接種,,導(dǎo)致新冠病毒給日本帶來的風(fēng)險(xiǎn)并沒有明顯減少。
疫苗接種
日本在批準(zhǔn)美國(guó)制藥業(yè)巨頭輝瑞(Pfizer)和德國(guó)疫苗制造商BioNTech開發(fā)的新冠疫苗幾天之后,,于2月17日正式啟動(dòng)疫苗接種,。這比美國(guó)等國(guó)家已經(jīng)落后了幾個(gè)月,但政府官員依舊樂觀地認(rèn)為日本能夠迎頭趕上,。
日本最初計(jì)劃在3月為370萬醫(yī)護(hù)人員接種疫苗,,而且菅義偉承諾在今年上半年,為日本1.26億人口保證足夠的疫苗供應(yīng),。
但截至4月21日,,日本僅施打了200多萬劑疫苗,相當(dāng)于只有1%的人口接種了疫苗,。
相比之下,,中國(guó)、美國(guó),、歐盟,、印度和巴西等其他大型經(jīng)濟(jì)體的疫苗接種工作已經(jīng)遙遙領(lǐng)先于日本。
日本表示,,疫苗供應(yīng)問題延誤了初期的接種工作,,并指責(zé)歐洲的出口限制導(dǎo)致日本無法確定疫苗分配計(jì)劃?!敦?cái)富》雜志曾經(jīng)咨詢?nèi)毡菊侥壳盀橹挂呀?jīng)取得了多少劑疫苗,,但并未得到回應(yīng)。
但有人認(rèn)為日本至少應(yīng)該承擔(dān)一定的責(zé)任,。
到目前為止,,日本嚴(yán)格的疫苗監(jiān)管制度僅批準(zhǔn)了輝瑞疫苗,它們要求疫苗生產(chǎn)商在日本完成安全性試驗(yàn)之后才可以獲得批準(zhǔn)。
日本也從英國(guó)阿斯利康和美國(guó)Moderna采購(gòu)了疫苗,,但衛(wèi)生部門尚未批準(zhǔn)這兩款疫苗,。
仙臺(tái)白百合女子大學(xué)的日本政治專家塞巴斯蒂安·馬斯洛指出,復(fù)雜的政府官僚政治可能讓情況變得更加復(fù)雜,。馬斯洛表示,,今年1月,日本任命行政改革擔(dān)當(dāng)大臣河野太郎主持疫苗分配工作,,這一決定可能使疫苗接種工作出現(xiàn)混亂,。
馬斯洛稱:“特別任命一位內(nèi)閣大臣負(fù)責(zé)協(xié)調(diào)疫苗分配讓情況變得更復(fù)雜”,因?yàn)椤耙呙缃臃N的具體工作”實(shí)際上是由衛(wèi)生部門負(fù)責(zé),。
馬斯洛說:“菅義偉政府的響應(yīng)速度極其緩慢,。”
但疫苗接種進(jìn)展緩慢有一部分原因是有意為之,。
日本當(dāng)局之所以比美國(guó)晚幾個(gè)月批準(zhǔn)輝瑞疫苗,,按照政府的說法是因?yàn)槿毡鞠M谌澜鐚?duì)是否接種疫苗最猶豫不決的時(shí)候,盡可能讓公眾樹立對(duì)疫苗的信心,。
醫(yī)學(xué)期刊《柳葉刀》在2020年9月發(fā)表的一項(xiàng)調(diào)查發(fā)現(xiàn),,認(rèn)為疫苗安全有效的日本受訪者不足30%,而美國(guó)受訪者的比例超過50%,。
最近幾個(gè)月,,公眾似乎認(rèn)可了新冠疫苗,并開始對(duì)政府的行動(dòng)遲緩日益不滿,。
東京大學(xué)在3月調(diào)查發(fā)現(xiàn),,62%的日本受訪者愿意接種新冠疫苗。4月12日,,日本共同社公布了對(duì)1,000名日本民眾的調(diào)查結(jié)果,,其中60%的受訪者表示“不滿意”政府的疫苗接種工作,表示滿意的只有37%,。
日本的疫苗生產(chǎn)
日本對(duì)外國(guó)疫苗的依賴引發(fā)了另外一個(gè)問題:日本作為全球第三大醫(yī)藥市場(chǎng),,有武田制藥、安斯泰來制藥和第一三共等行業(yè)巨頭,,為什么國(guó)內(nèi)沒有開發(fā)出有效的新冠疫苗,?
世界衛(wèi)生組織的報(bào)告稱,截至4月20日,,全世界已經(jīng)有91款新冠疫苗開始進(jìn)行人體試驗(yàn),。其中有四款是日本疫苗,但日本企業(yè)都沒有完成三期臨床試驗(yàn),,而三期臨床試驗(yàn)是獲得監(jiān)管審批之前的最后一步,。
誕生于大阪大學(xué)的初創(chuàng)制藥公司AnGes Inc.在日本新冠疫苗開發(fā)方面進(jìn)展最快,。該公司在去年12月啟動(dòng)了基于DNA的候選疫苗的二期和三期臨床試驗(yàn),。
日本藥企第一三共正在開發(fā)一款mRNA疫苗,。該公司表示其疫苗最早要在2022年4月才能夠上市?!度毡緯r(shí)報(bào)報(bào)道稱,,日本制藥行業(yè)業(yè)內(nèi)人士同樣預(yù)計(jì),最早要到明年4月才會(huì)有日本國(guó)產(chǎn)疫苗上市,。
疫苗產(chǎn)能似乎并不是日本疫苗開發(fā)面臨的主要障礙,,因?yàn)槿毡舅幤笈c外國(guó)藥企達(dá)成了大規(guī)模生產(chǎn)疫苗的協(xié)議。
日本藥企第一三共,、KM Biologics和JCR Pharmaceuticals每年將合作生產(chǎn)1.2億劑阿斯利康的疫苗,。武田制藥則與美國(guó)藥企Novavax合作,每年在日本生產(chǎn)2.5億劑新冠疫苗,。
馬斯洛表示,,由于缺乏政府支持,日本的疫苗開發(fā)系統(tǒng)不能與美國(guó)等國(guó)家的同行一樣幫助推動(dòng)創(chuàng)新,。
馬斯洛稱:“多年來,,日本始終沒有為科研和疫苗開發(fā)提供足夠的財(cái)政支持?!?/p>
日本確實(shí)向疫苗生產(chǎn)商撥款近30億美元,,以促進(jìn)新冠疫苗的開發(fā)。但這筆投資顯然遠(yuǎn)遠(yuǎn)低于諸如投入180億的“曲速行動(dòng)”等旨在加快新冠疫苗開發(fā)的項(xiàng)目,。
日本政府對(duì)疫苗開發(fā)工作的支持不足,,部分原因可以追溯到幾十年前的疫苗丑聞。
20世紀(jì)80年代末和90年代初,,麻疹,、腮腺炎、風(fēng)疹三聯(lián)疫苗在日本被曝出可能與類似于流感的少量無菌性腦膜炎病例有關(guān),,盡管這種疫苗在全世界已經(jīng)使用了數(shù)十年,,其安全性和療效也得到了證明。
90年代初,,因?yàn)楹⒆咏臃N疫苗后出現(xiàn)嚴(yán)重副作用而提起訴訟的三個(gè)家庭勝訴,,其中有兩名兒童死亡。法院裁定日本政府因?yàn)橥扑]接種這款疫苗,,需要對(duì)此負(fù)責(zé),。
事后,日本停止接種MMR疫苗,,直到今天,,它依舊是少數(shù)不使用這款疫苗的主要經(jīng)濟(jì)體之一。
威爾遜中心的地理經(jīng)濟(jì)學(xué)副主任藤志保子表示,MMR疫苗以及其他疫苗爭(zhēng)議的影響妨礙了日本疫苗開發(fā)行業(yè)的發(fā)展,,讓政府在選擇支持疫苗制造商時(shí)變得更加謹(jǐn)慎,。
面對(duì)新冠疫情,日本對(duì)待疫苗小心謹(jǐn)慎的態(tài)度導(dǎo)致政府和制藥商將重心放到開發(fā)治療藥物而不是疫苗,,例如富士膠片的流感藥物Avigan,。這款藥物在減少新冠肺炎癥狀方面的結(jié)果好壞參半。
藤志保子稱:“日本的應(yīng)對(duì)方式并不是開發(fā)疫苗,,而是寧可小心謹(jǐn)慎,,也不愿意冒風(fēng)險(xiǎn)?!毕喾?,她表示:“日本政府把所有雞蛋都放到了‘治療藥物’這個(gè)籃子里,但事情的發(fā)展卻并不像他們所想象的那樣,?!?/p>
從根本上來說,日本應(yīng)對(duì)新冠病毒的表現(xiàn),,要好于美國(guó)和歐洲國(guó)家,。但其在研發(fā)和接種疫苗方面進(jìn)展緩慢,可能成為三個(gè)月后舉辦奧運(yùn)會(huì)面臨的致命弱點(diǎn),。(財(cái)富中文網(wǎng))
翻譯:劉進(jìn)龍
審校:汪皓
The Tokyo Olympic Games are less 90 days away.
But after nearly a year of preparation for the suspended 2020 Olympics, which were supposed to take place last summer, Japan’s sluggish vaccine rollout has left the vast majority of its citizens unprotected from COVID-19 as the country battles a new surge of infections.
On April 23, Japan’s Economy Minister, Yasutoshi Nishimura, announced that Tokyo, Osaka, and two prefectures will enter a state of emergency starting on April 25. The country is now recording over 5,000 new cases per day, marking its second-biggest wave of infections after its previous peak in January of this year.
The measures Nishimura announced on April 23 will be among the most stringent Japan has imposed since the beginning of the pandemic. They will call on large bars and restaurants to close and ban spectators from attending sporting events until May 11.
The surge in cases prompted Toshihiro Nikai, secretary-general of Prime Minister Yoshihide Suga’s Liberal Democratic Party, last week to question Tokyo’s ability to host the Olympics.
But before the emergency measures were announced, Suga on April 20 stressed that the policy would not have a bearing on the Summer Games.
“There will be no impact on the Olympics,” he told reporters on April 20. “The government will do its best to host the Games in safety.”
Japan has banned foreign fans from attending the Games, and has released a series of rules that aim to prevent athletes, officials, and media members from catching and spreading the virus once they are in Tokyo.
No one attending that Games is required to be vaccinated, but athletes, for example, will be tested for COVID when they arrive and then periodically throughout their stay. They are not allowed to eat or congregate with one another and must avoid physical interactions like high fives and handshakes. Still, experts fear that the measures may not be enough to curb the threat of a superspreader event with tens of thousands of athletes, coaches, and delegates from 93 countries planning to descend on Tokyo in 13 weeks’ time.
The concerns over the Olympics and the recent surge in infections have put a spotlight on the country’s lagging vaccine campaign, which has failed to provide access to vaccines to most Japanese citizens and trails that of other major economies.
Japan, the world’s third-largest economy, does not lack the resources or capacity to purchase, distribute, or even manufacture COVID-19 vaccines. But even with the added pressure of hosting the Olympics during a pandemic, Japan has opted for a slow and steady approach to COVID-19 vaccines that has left the country only marginally less exposed to a virus that forced Tokyo to suspend the Olympics nearly one year ago.
The rollout
Japan officially launched its COVID-19 vaccination drive on Feb. 17, days after approving the COVID-19 vaccine developed by U.S. pharmaceutical giant Pfizer and German vaccine maker BioNTech. It started months after rollouts in countries like the U.S., but officials were optimistic that Japan could catch up.
Japan aimed to vaccinate its 3.7 million health care workers in March, and Suga pledged to secure enough doses for Japan’s 126 million people in the first half of the year.
But as of April 21, Japan has administered just over 2 million vaccine shots to its citizens, which translates to at least one vaccine dose for 1% of its population.
The U.S., by comparison, has administered 216 million shots, enough for 40.5% of Americans to get one dose. Other large economies like the European Union, China, India, and Brazil have also surged ahead of Japan in their own campaigns.
Japan says that supply issues slowed the initial rollout, and it accused European export curbs of delaying Japan’s ability to finalize its distribution plan. The Japanese government did not respond to Fortune’s request for comment on how many doses it has secured thus far.
But others say that Japan deserves at least some of the blame.
Japan’s stringent vaccine regulatory system has approved only Pfizer’s vaccine so far. Japan requires vaccine makers to conduct safety trials in the country before approval. Japan has purchased additional vaccines from the U.K.’s AstraZeneca and the U.S.’s Moderna, but the country’s health ministry has not yet approved either vaccine.
Complicated government bureaucracy may be adding to the problem, says Sebastian Maslow, a Japanese politics expert at Sendai Shirayuri Women’s College in Japan. In January of this year, Japan appointed Reform and Regulatory Minister Taro Kono to handle vaccine distribution, which may have muddled inoculation efforts, says Maslow.
“The creation of a specially appointed minister in charge for coordinating vaccine distribution has complicated the process,” he notes, given that the health ministry is “actually in charge of putting the vaccines into people’s arms.”
“The Suga government’s response has been extremely slow,” says Maslow.
But some of the sluggishness was intentional.
Japanese authorities approved the Pfizer vaccine months after counterparts in the U.S., in part, because Japanese authorities said they wanted to instill as much confidence as possible in a public that is among the most vaccine-hesitant in the world.
A survey published in September 2020 by the Lancet medical journal found that fewer than 30% of Japanese respondents agreed that vaccines were safe and effective, as opposed to over 50% of American respondents.
In recent months, the public appears to have warmed up to COVID-19 vaccines and has grown frustrated by the government’s slow administration of them.
Tokyo University found in a March survey that 62% of Japanese respondents were willing to get a COVID-19 jab. On April 12, Japan’s Kyodo News published a poll of 1,000 Japanese citizens, 60% of whom said they were “dissatisfied” with the government’s vaccine drive, compared with 37% who said they were satisfied with the effort.
Japan vaccine manufacturing
Japan’s reliance on foreign-made vaccines raises the question of why the world’s third-largest pharmaceutical market, which boasts domestic giants like Takeda Pharmaceutical, Astellas Pharma, and Daiichi Sankyo, has not developed its own proven COVID-19 vaccine.
The World Health Organization reports that as of April 20, 91 COVID-19 vaccines have reached human trials around the world. Japanese vaccines account for four of the vaccines on the list, but none of the Japanese firms have completed Phase III clinical trials, the final step before regulatory approval.
AnGes Inc., a pharmaceutical startup that emerged from Osaka University, is the farthest along of any Japanese firm in developing a COVID-19 vaccine. The firm launched Phase II and III trials with its DNA-based candidate in December.
Japanese drugmaker Daiichi Sankyo, which is developing a mRNA vaccine, says that its vaccine will not be ready until April 2022 at the earliest. The Japan Times reports that pharmaceutical industry insiders in Japan similarly do not expect any Japan-made vaccine to be ready until at least April of next year.
Vaccine manufacturing capacity does not appear to be a major hurdle in drug development since Japanese firms have struck large manufacturing deals with foreign drugmakers.
Japanese pharmaceutical firms Daiichi Sankyo, KM Biologics, and JCR Pharmaceuticals are partnering to produce 120 million doses of AstraZeneca’s vaccine annually. The pharmaceutical firm Takeda, meanwhile, is partnering with U.S. drugmaker Novavax to make 250 million COVID-19 vaccine shots in Japan each year.
Maslow says that Japan’s vaccine development system may not be as conducive to driving innovation as those in places like the U.S. owing to a lack of government support.
“Japan has over many years failed to provide sufficient financial support for research and vaccination development,” Maslow says.
To be sure, Japan has granted vaccine makers nearly $3 billion to promote the development of COVID-19 vaccines. But that investment is small compared with the U.S.’s Operation Warp Speed, the program to develop COVID-19 vaccines that received at least $18 billion in government funding.
Japan’s lack of governmental vaccine support can be traced, in part, to a vaccine scandal from decades ago.
In the late 1980s and early 1990s, Japan linked a small number of cases of aseptic meningitis, a flu-like illness, to people vaccinated with a measles, mumps, and rubella (MMR) vaccine, even though the vaccine had proved safe and effective in decades of use around the world. In the early 1990s, three families of children who had severe side effects after receiving the vaccine, including two children who died, won lawsuits that held the government responsible, since it recommended the vaccine. Afterward, Japan discontinued the use of MMR, and it remains one of the only major economies not to use the vaccine today.
The fallout of the MMR and other vaccine controversies stifled Japan’s vaccine development industry and made the government more cautious in its approach to supporting vaccine makers, says Shihoko Goto, deputy director for geoeconomics at the Wilson Center.
When it came to COVID-19, Japan’s wary approach to vaccines led the government and drugmakers to focus on treatment options like Fujifilm’s Avigan flu-fighting drug, which has demonstrated mixed results in reducing COVID-19 symptoms, instead of vaccines.
“Japan’s approach has not been to develop vaccines…and to err on the side of caution,” says Goto. Instead, she says, “they put all their eggs in the cure basket, and that has not really panned out the way they want it to.”
Ultimately, Japan has performed better in battling the virus than many of its peers in the U.S. and Europe. But its lack of speed on developing and rolling out vaccines may prove an Achilles’ heel as it prepares to host the Olympic Games three months from now.